Mutagenic specificity in reovirus
نویسندگان
چکیده
منابع مشابه
Specificity in transcription of the reovirus genome.
Reovirus contains double-stranded ribonucleic acid with a molecular weight of approximately 107 daltons. 1 2 This RNA exists in the virion as a continuous linear structure, but it is extraordinarily susceptible to breakage.3-5 When isolated by any of the commonly used extraction techniques, the major portion of viral RNA appears as fragments with lengths of 0.35 ,u, 0.6 gA, and 1.1 jA, correspo...
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The specificity of protein synthesis in reovirus-infected mouse SC-1 cells was investigated, with the following results: a, extracts from infected and control cells translated saturating levels of capped globin mRNA with the same efficiency; b, infected cell extracts did not display a virus-induced increase in the capacity to translate decapped globin mRNA; c, translation of both cellular and v...
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Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses. Other major advantages of OVs are that they dose-escalate in tumors and can be genetically engineered to enhance potency and specificity. Unmodified wild type reovirus is a propit...
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The in vivo mutational specificity of a novel T4 DNA polymerase mutator mutant, tsM19, was determined. Two genetic tester systems were used to characterize the mutant. Results of our studies indicate that tsM19 promotes transition and transversion mutagenesis and, possibly, frameshift mutagenesis. Central G:C base pairs in runs of three or more consecutive G:C base pairs may be target sites for...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1979
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.30.3.913-916.1979